Posaconazole

Product Details

Product Description:

Product Name: Posaconazole CAS NO: 171228-49-2

Synonyms:

4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one;

Chemical & Physical Properties:

Appearance : White solid

Assay :≥99.0%

Density: 1.36g/cm3

Boiling Point: 850.7℃ at 760 mmHg

Flash Point:468.3℃

Melting Point:170-172℃

Posaconazole (posaconazole) is derived from itraconazole. Its pharmacological effects are similar with azoles, but compared with itraconazole, it has a stronger inhibitory effect on the C14 demethylation of steroid, especially for Aspergillus.

 It can be clinically used for the treatment of aspergillosis, zygnmycosis, and fusariumsis and can also be used for infection caused by part of fluconazole-resistant Candida genus. Studies have shown that posaconazole can widely and effectively applied to the treatment of phaeohyphomycosis and improve the infection survival rate of dermatitidis infection in a dose-dependent manner. 

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